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Polymer Synthesis Capabilities
Rapidly Advancing the Field of Biotherapeutics

Critical for all polymer-based development projects is the ability to combine monomers into longer-chained polymers that retain the desirable characteristics of the initial building blocks. This technology has been applied to plastics and adhesives in a number of industries. Now, biopolymers are being utilized to incorporate DNA, siRNA and proteins into biological systems, which are rapidly advancing the field of biotherapeutics.
Fueled by these types of advancements, another Nitto Denko company, Kinovate Life Sciences, Inc., developed and recently launched a biodegradable polymer-based vector. Through proprietary methods, genetic material is successfully combined with a polymer that facilitates the cell-specific entry of nucleic acids. After endocytosis, the genetic material is released through the nuclear membrane and the polymer is biodegraded to small, nontoxic molecules, which eventually get released from the cell and excreted through the urine. This particular type of gene delivery is associated with a low level of cytotoxicity and is extremely stable.
Biodegradable Transfection Reagent

| Biodegradable mode of
action: (1) Attachment and endocytosis; (2) Endosome escape; (3) Nuclear localization; (4) Degradation and DNA release. |
These advances in polymer synthesis capabilities have enabled the applicability of our technologies in the following areas:
- Large-molecule passive transdermal drug delivery systems with the first vaccine-in-adhesive patch
- Biologics
- Biodegradable transfection reagents (CytoPure™ Transfection Reagent)
Visit Kinovate Life Sciences, Inc. for more information on our polymer synthesis capabilities.
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