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Sustained Release  A sustained release is facilitated through the consistent rejuvenation of drug molecules at the surface of the skin. This abundant supply of active drug is maintained by dissolving crystals in the adhesive polymer matrix. From this, blood concentrations of drug increase at a steady rate (much slower than a burst release) with an extended plateau. This type of release is comparable to intravenous infusion. This method is incorporated in the isosorbide dinitrate transdermal system, which was developed by Nitto Denko. For more information, click on: |
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